Cell-free DNA in blood and urine as a diagnostic tool for bladder cancer: a meta-analysis.
Am J Transl Res
; 10(7): 1935-1948, 2018.
Article
in En
| MEDLINE
| ID: mdl-30093933
ABSTRACT
OBJECTIVE:
To assess the diagnostic performance of cell-free DNA assays in the detection of bladder cancer. PATIENTS ANDMETHODS:
The quality of the studies included in this meta-analysis was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Statistical analyses were performed using the software RevMan 5.3 and Stata 14.0. We assessed the pooled sensitivity and specificity, positive/negative likelihood ratios (PLRs/NLRs), diagnostic odds ratios (DORs), and corresponding 95% confidence intervals (95% CIs). Summary receiver operating characteristic curve (ROC curve) and area under the curve (AUC) were used to summarize the overall test performance. Heterogeneity and publication bias were also examined.RESULTS:
Eleven studies included 802 bladder cancer patients and 668 controls met the eligibility criteria. The overall diagnostic accuracy was measured as follows sensitivity 0.71 (95% CI = 0.64-0.77), specificity 0.78 (95% CI = 0.70-0.85), PLR 3.3 (95% CI = 2.4-54.5), NLR 0.37 (95% CI = 0.30-0.46), DOR 9 (95% CI = 6-14), and AUC 0.80 (95% CI = 0.77-0.83). Subgroup analysis suggested that ethnicity significantly accounted for the heterogeneity of specificity. The Deeks' funnel plot asymmetry test (P = 0.97) suggested no potential publication bias.CONCLUSIONS:
Cell-free DNA has a high diagnostic value in bladder cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Language:
En
Journal:
Am J Transl Res
Year:
2018
Document type:
Article
Affiliation country:
China