Cardiac myocyte proliferation and maturation near term is inhibited by early gestation maternal testosterone exposure.

Jonker, Sonnet S; Louey, Samantha; Roselli, Charles E

Jonker, Sonnet S; Louey, Samantha; Roselli, Charles E.

Affiliation

Jonker SS; Center for Developmental Health, Oregon Health & Science University , Portland, Oregon.
Louey S; Knight Cardiovascular Institute, Oregon Health & Science University , Portland, Oregon.
Roselli CE; Center for Developmental Health, Oregon Health & Science University , Portland, Oregon.

Am J Physiol Heart Circ Physiol ; 315(5): H1393-H1401, 2018 11 01.

Article in En | MEDLINE | ID: mdl-30095996

Subject(s)

Cell Differentiation; Cell Proliferation; Fetal Growth Retardation/pathology; Fetal Heart/pathology; Myocytes, Cardiac/pathology; Testosterone Propionate; Animals; Disease Models, Animal; Female; Fetal Growth Retardation/blood; Fetal Growth Retardation/chemically induced; Fetal Heart/metabolism; Gestational Age; Insulin-Like Growth Factor I/metabolism; Ki-67 Antigen/metabolism; Male; Maternal Exposure; Myocytes, Cardiac/metabolism; Pregnancy; Sex Factors; Sheep, Domestic

Key words

androgens; cardiac growth and development; intrauterine growth restriction; ovine; sex differences

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Myocytes, Cardiac / Testosterone Propionate / Cell Proliferation / Fetal Growth Retardation / Fetal Heart Type of study: Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2018 Document type: Article Country of publication: United States

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