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The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6.
Tengesdal, Isak W; Kitzenberg, David; Li, Suzhao; Nyuydzefe, Melanie S; Chen, Wei; Weiss, Jonathan M; Zhang, Jingya; Waksal, Samuel D; Zanin-Zhorov, Alexandra; Dinarello, Charles A.
Affiliation
  • Tengesdal IW; Dept. Medicine, University of Colorado Denver, Aurora, CO, USA.
  • Kitzenberg D; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Li S; Dept. Medicine, University of Colorado Denver, Aurora, CO, USA.
  • Nyuydzefe MS; Dept. Medicine, University of Colorado Denver, Aurora, CO, USA.
  • Chen W; Kadmon Corporation, LLC, New York, NY, USA.
  • Weiss JM; Kadmon Corporation, LLC, New York, NY, USA.
  • Zhang J; Kadmon Corporation, LLC, New York, NY, USA.
  • Waksal SD; Kadmon Corporation, LLC, New York, NY, USA.
  • Zanin-Zhorov A; Kadmon Corporation, LLC, New York, NY, USA.
  • Dinarello CA; Kadmon Corporation, LLC, New York, NY, USA.
Eur J Immunol ; 48(10): 1679-1686, 2018 10.
Article in En | MEDLINE | ID: mdl-30098001

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukocytes, Mononuclear / Interleukin-6 / Interleukin-17 / Interleukin-1alpha / Rho-Associated Kinases / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Eur J Immunol Year: 2018 Document type: Article Affiliation country: United States Country of publication: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukocytes, Mononuclear / Interleukin-6 / Interleukin-17 / Interleukin-1alpha / Rho-Associated Kinases / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Eur J Immunol Year: 2018 Document type: Article Affiliation country: United States Country of publication: Germany