The Genesis of the Neuroendocrine Tumors Concept: From Oberndorfer to 2018.
Endocrinol Metab Clin North Am
; 47(3): 711-731, 2018 09.
Article
in En
| MEDLINE
| ID: mdl-30098726
ABSTRACT
The concept of neuroendocrine tumors (NETs) began in the 1900s with Oberndorfer's description of carcinoid tumors, followed by specific cytotoxic agents and the identification of somatostatin. NETs diagnosis was confirmed by World Health Organization classification. Histopathology included immunohistochemistry with specific antibodies. Imaging was refined with molecular imaging. Somatostatin is the leading agent for controlling clinical symptoms related to hormone production. Increasing interest in these tumors, previously thought rare, led to increased incidence and prevalence. Between 1960 and 1970, the true NET-concept was established with development of radioimmunoassays for peptides and hormones, and imaging with computerized tomography.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neuroendocrine Tumors
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Endocrinol Metab Clin North Am
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
2018
Document type:
Article