Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design.

Zhang, Xin-Yu; Elfarra, Adnan A

Zhang, Xin-Yu; Elfarra, Adnan A.

Affiliation

Zhang XY; a Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Elfarra AA; b Department of Comparative Biosciences and the Molecular and Environmental Toxicology Center , University of Wisconsin-Madison , Madison , WI , USA.

Expert Opin Drug Discov ; 13(9): 815-824, 2018 09.

Article in En | MEDLINE | ID: mdl-30101640

Subject(s)

Antineoplastic Agents/administration & dosage; Mercaptopurine/administration & dosage; Thioguanine/administration & dosage; Animals; Antineoplastic Agents/adverse effects; Antineoplastic Agents/metabolism; Drug Design; Glutathione/metabolism; Glutathione Transferase/metabolism; Humans; Kidney/metabolism; Mercaptopurine/adverse effects; Mercaptopurine/metabolism; Molecular Targeted Therapy; Neoplasms/drug therapy; Prodrugs; Thioguanine/adverse effects; Thioguanine/metabolism

Key words

6-Mercaptopurine; 6-thioguanine; Michael addition; anticancer prodrug design; bioactivation; cysteine S-conjugate ß-lyases; glutathione; trichloroethylene; tumor cell-selective prodrug

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioguanine / Mercaptopurine / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Expert Opin Drug Discov Year: 2018 Document type: Article Affiliation country: China Country of publication: United kingdom

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