FasL on the surface of Tag7 (PGRP-S)-activated lymphocytes induces necroptosis in HLA-negative tumor cells with the involvement of lysosomes and mitochondria.

Sharapova, Tatiana N; Romanova, Elena A; Sashchenko, Lidia P; Yashin, Denis V

Sharapova, Tatiana N; Romanova, Elena A; Sashchenko, Lidia P; Yashin, Denis V.

Affiliation

Sharapova TN; IBG RAS, Vavilova 34/5, Moscow, Russia.
Romanova EA; IBG RAS, Vavilova 34/5, Moscow, Russia.
Sashchenko LP; IBG RAS, Vavilova 34/5, Moscow, Russia. Electronic address: sashchenko@genebiology.ru.
Yashin DV; IBG RAS, Vavilova 34/5, Moscow, Russia.

Biochimie ; 152: 174-180, 2018 Sep.

Article in En | MEDLINE | ID: mdl-30103900

Subject(s)

Apoptosis; Cytokines/metabolism; Fas Ligand Protein/metabolism; HLA Antigens/metabolism; Lymphocyte Activation; Lysosomes/metabolism; Mitochondria/metabolism; Calpain/metabolism; Enzyme Activation; Humans; K562 Cells; Necrosis; Phospholipases A2/metabolism; Reactive Oxygen Species/metabolism; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism; STAT3 Transcription Factor/metabolism; Signal Transduction

Key words

FasL; Necroptosis; RIP1; STAT3; Tag7

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / Cytokines / Apoptosis / Fas Ligand Protein / HLA Antigens / Lysosomes / Mitochondria Limits: Humans Language: En Journal: Biochimie Year: 2018 Document type: Article Affiliation country: RUSSIA Country of publication: France

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