Identification of N-Hydroxycinnamamide analogues and their bio-evaluation against breast cancer cell lines.
Biomed Pharmacother
; 107: 475-483, 2018 Nov.
Article
in En
| MEDLINE
| ID: mdl-30107343
ABSTRACT
The present study demonstrates the identification of N-hydroxycinnamamide derivatives and their anticancer potential against human triple-negative breast cancer cell line MDA-MB231, MCF-7 and non-malignant origin cell line, HEK-293 (human embryonic kidney). MTT assay was studied with HEK-293 cell line. Anticancer potential of the N-hydroxycinnamamide derivatives were compared with marked drug Tamoxifen through in vitro study. The compound numbers 3b and 3h exhibit most potent activity against antagonistic breast cancer cells (MDA-MB-231) with IC5013µM and 5µM respectively. Compound 3h promotes DNA fragmentation and induction of apoptosis. Furthermore, loss of mitochondrial membrane potential induced by compound 3h. The major mechanism of compound 3h for anti-breast cancer activity was probably initiation of reactive oxygen species (ROS) in cancer cells thereby persuading apoptotic cell deaths in cancer cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Cinnamates
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Biomed Pharmacother
Year:
2018
Document type:
Article
Affiliation country:
India