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Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model.
Tellegen, A R; Rudnik-Jansen, I; Beukers, M; Miranda-Bedate, A; Bach, F C; de Jong, W; Woike, N; Mihov, G; Thies, J C; Meij, B P; Creemers, L B; Tryfonidou, M A.
Affiliation
  • Tellegen AR; Department of Clinical Sciences of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
  • Rudnik-Jansen I; Department of Orthopedics, University Medical Centre Utrecht, The Netherlands.
  • Beukers M; Department of Clinical Sciences of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
  • Miranda-Bedate A; Department of Clinical Sciences of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
  • Bach FC; Department of Clinical Sciences of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
  • de Jong W; Department of Clinical Sciences of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
  • Woike N; DSM Biomedical, Geleen, The Netherlands.
  • Mihov G; DSM Biomedical, Geleen, The Netherlands.
  • Thies JC; DSM Biomedical, Geleen, The Netherlands.
  • Meij BP; Department of Clinical Sciences of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
  • Creemers LB; Department of Orthopedics, University Medical Centre Utrecht, The Netherlands.
  • Tryfonidou MA; Department of Clinical Sciences of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. Electronic address: m.a.tryfonidou@uu.nl.
J Control Release ; 286: 439-450, 2018 09 28.
Article in En | MEDLINE | ID: mdl-30110616
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyesters / Delayed-Action Preparations / Cyclooxygenase 2 Inhibitors / Intervertebral Disc Degeneration / Celecoxib Type of study: Observational_studies / Prognostic_studies Limits: Animals Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: Netherlands Country of publication: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyesters / Delayed-Action Preparations / Cyclooxygenase 2 Inhibitors / Intervertebral Disc Degeneration / Celecoxib Type of study: Observational_studies / Prognostic_studies Limits: Animals Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: Netherlands Country of publication: Netherlands