Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction.

Chen, Justin Y; Parekh, Miloni; Seliman, Hadear; Bakshinskaya, Dariya; Dai, Wei; Kwan, Kelvin; Chen, Kuang Yu; Liu, Alice Y C

Chen, Justin Y; Parekh, Miloni; Seliman, Hadear; Bakshinskaya, Dariya; Dai, Wei; Kwan, Kelvin; Chen, Kuang Yu; Liu, Alice Y C.

Affiliation

Chen JY; From the Department of Cell Biology and Neuroscience and.
Parekh M; From the Department of Cell Biology and Neuroscience and.
Seliman H; From the Department of Cell Biology and Neuroscience and.
Bakshinskaya D; From the Department of Cell Biology and Neuroscience and.
Dai W; From the Department of Cell Biology and Neuroscience and.
Kwan K; From the Department of Cell Biology and Neuroscience and.
Chen KY; Department of Chemistry and Chemical Biology, Rutgers State University of New Jersey, Piscataway, New Jersey 08854.
Liu AYC; From the Department of Cell Biology and Neuroscience and liu@dls.rutgers.edu.

J Biol Chem ; 293(40): 15581-15593, 2018 10 05.

Article in En | MEDLINE | ID: mdl-30143534

Subject(s)

Heat Shock Transcription Factors/genetics; Heat-Shock Response; Huntingtin Protein/genetics; Huntington Disease/genetics; Inclusion Bodies/metabolism; Neurons/metabolism; Animals; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cell Nucleus/pathology; Corpus Striatum/metabolism; Corpus Striatum/pathology; Cyclic AMP Response Element-Binding Protein/genetics; Cyclic AMP Response Element-Binding Protein/metabolism; Cytosol/drug effects; Cytosol/metabolism; Cytosol/pathology; Ecdysterone/analogs & derivatives; Ecdysterone/pharmacology; Embryo, Mammalian; Gene Expression Regulation; HSC70 Heat-Shock Proteins/genetics; HSC70 Heat-Shock Proteins/metabolism; HSP70 Heat-Shock Proteins/genetics; HSP70 Heat-Shock Proteins/metabolism; Heat Shock Transcription Factors/metabolism; Huntingtin Protein/metabolism; Huntington Disease/chemically induced; Huntington Disease/metabolism; Huntington Disease/pathology; Inclusion Bodies/chemistry; Inclusion Bodies/drug effects; Models, Biological; Mutation; NF-kappa B/genetics; NF-kappa B/metabolism; Neurons/drug effects; Neurons/pathology; PC12 Cells; Primary Cell Culture; Rats; Sorbitol/pharmacology

Key words

CREB; HSP chaperones; Huntington's disease; aggregation; chaperone; heat shock; heat shock factor protein 1 (HSF1); heat shock protein (HSP); inclusion bodies; neurodegeneration; polyQ-mHtt protein; transcription factor sequestration

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inclusion Bodies / Huntington Disease / Heat-Shock Response / Huntingtin Protein / Heat Shock Transcription Factors / Neurons Type of study: Prognostic_studies Language: En Journal: J Biol Chem Year: 2018 Document type: Article Country of publication: United States

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