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Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
King, Andrew J; Siegel, Matthew; He, Ying; Nie, Baoming; Wang, Ji; Koo-McCoy, Samantha; Minassian, Natali A; Jafri, Qumber; Pan, Deng; Kohler, Jill; Kumaraswamy, Padmapriya; Kozuka, Kenji; Lewis, Jason G; Dragoli, Dean; Rosenbaum, David P; O'Neill, Debbie; Plain, Allein; Greasley, Peter J; Jönsson-Rylander, Ann-Cathrine; Karlsson, Daniel; Behrendt, Margareta; Strömstedt, Maria; Ryden-Bergsten, Tina; Knöpfel, Thomas; Pastor Arroyo, Eva M; Hernando, Nati; Marks, Joanne; Donowitz, Mark; Wagner, Carsten A; Alexander, R Todd; Caldwell, Jeremy S.
Affiliation
  • King AJ; Ardelyx Inc., Fremont, CA 94555, USA. aking@ardelyx.com.
  • Siegel M; Ardelyx Inc., Fremont, CA 94555, USA.
  • He Y; Ardelyx Inc., Fremont, CA 94555, USA.
  • Nie B; Ardelyx Inc., Fremont, CA 94555, USA.
  • Wang J; Ardelyx Inc., Fremont, CA 94555, USA.
  • Koo-McCoy S; Ardelyx Inc., Fremont, CA 94555, USA.
  • Minassian NA; Ardelyx Inc., Fremont, CA 94555, USA.
  • Jafri Q; Ardelyx Inc., Fremont, CA 94555, USA.
  • Pan D; Ardelyx Inc., Fremont, CA 94555, USA.
  • Kohler J; Ardelyx Inc., Fremont, CA 94555, USA.
  • Kumaraswamy P; Ardelyx Inc., Fremont, CA 94555, USA.
  • Kozuka K; Ardelyx Inc., Fremont, CA 94555, USA.
  • Lewis JG; Ardelyx Inc., Fremont, CA 94555, USA.
  • Dragoli D; Ardelyx Inc., Fremont, CA 94555, USA.
  • Rosenbaum DP; Ardelyx Inc., Fremont, CA 94555, USA.
  • O'Neill D; University of Alberta, Edmonton, Alberta T6G 1C9, Canada.
  • Plain A; University of Alberta, Edmonton, Alberta T6G 1C9, Canada.
  • Greasley PJ; Cardiovascular and Metabolic Disease (CVMD) Translational Medicine Unit, Early Clinical Development, Innovative Medicines and Early Development (IMED) Biotech Unit, AstraZeneca Gothenburg, 431 50 Mölndal, Sweden.
  • Jönsson-Rylander AC; Bioscience, CVMD, IMED Biotech Unit, AstraZeneca Gothenburg, 431 50 Mölndal, Sweden.
  • Karlsson D; Bioscience, CVMD, IMED Biotech Unit, AstraZeneca Gothenburg, 431 50 Mölndal, Sweden.
  • Behrendt M; Bioscience, CVMD, IMED Biotech Unit, AstraZeneca Gothenburg, 431 50 Mölndal, Sweden.
  • Strömstedt M; Bioscience, CVMD, IMED Biotech Unit, AstraZeneca Gothenburg, 431 50 Mölndal, Sweden.
  • Ryden-Bergsten T; CVMD, IMED Biotech Unit, AstraZeneca Gothenburg, 431 50 Mölndal, Sweden.
  • Knöpfel T; Institute of Physiology, University of Zurich and National Center of Competence in Research Kidney Control of Homeostasis, CH-8057 Zurich, Switzerland.
  • Pastor Arroyo EM; Institute of Physiology, University of Zurich and National Center of Competence in Research Kidney Control of Homeostasis, CH-8057 Zurich, Switzerland.
  • Hernando N; Institute of Physiology, University of Zurich and National Center of Competence in Research Kidney Control of Homeostasis, CH-8057 Zurich, Switzerland.
  • Marks J; Department of Neuroscience, Physiology and Pharmacology, University College London, Royal Free Campus, London NW3 2PF, UK.
  • Donowitz M; Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Wagner CA; Institute of Physiology, University of Zurich and National Center of Competence in Research Kidney Control of Homeostasis, CH-8057 Zurich, Switzerland.
  • Alexander RT; University of Alberta, Edmonton, Alberta T6G 1C9, Canada.
  • Caldwell JS; Ardelyx Inc., Fremont, CA 94555, USA.
Sci Transl Med ; 10(456)2018 08 29.
Article in En | MEDLINE | ID: mdl-30158152
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphates / Sulfonamides / Cell Membrane Permeability / Gastrointestinal Tract / Sodium-Hydrogen Exchanger 3 / Isoquinolines Type of study: Clinical_trials Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphates / Sulfonamides / Cell Membrane Permeability / Gastrointestinal Tract / Sodium-Hydrogen Exchanger 3 / Isoquinolines Type of study: Clinical_trials Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States