Characterization and effect of metal ions on the formation of the Thermus thermophilus Sco mixed disulfide intermediate.

Lopez, Liezelle C; Mukhitov, Nikita; Handley, Lindsey D; Hamme, Cristina S; Hofman, Cristina R; Euers, Lindsay; McKinney, Jennifer R; Piers, Amani D; Wadler, Ellen; Hunsicker-Wang, Laura M

Lopez, Liezelle C; Mukhitov, Nikita; Handley, Lindsey D; Hamme, Cristina S; Hofman, Cristina R; Euers, Lindsay; McKinney, Jennifer R; Piers, Amani D; Wadler, Ellen; Hunsicker-Wang, Laura M.

Affiliation

Lopez LC; Department of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas, 78212-7200.
Mukhitov N; Baylor School of Medicine, One Baylor Plaza, Houston, Texas, 77030.
Handley LD; Department of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas, 78212-7200.
Hamme CS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139.
Hofman CR; Department of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas, 78212-7200.
Euers L; ThoughtSTEM, San Diego, California, 92108.
McKinney JR; Department of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas, 78212-7200.
Piers AD; Lone Star Family Health Center, Conroe, Texas, 77034.
Wadler E; Department of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas, 78212-7200.
Hunsicker-Wang LM; Department of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas, 78212-7200.

Protein Sci ; 27(11): 1942-1954, 2018 11.

Article in En | MEDLINE | ID: mdl-30168216

Subject(s)

Bacterial Proteins/chemistry; Copper/chemistry; Disulfides/chemistry; Ions/chemistry; Thermus thermophilus/chemistry; Amino Acid Sequence; Amino Acids/chemistry; Binding Sites; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Oxidation-Reduction; Protein Binding; Protein Conformation; Solvents/chemistry

Key words

CuA; Sco; TNB; copper metal binding; disulfide bonds; metalloproteins; mixed disulfide intermediate; thiol-disulfide oxidoreductase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Thermus thermophilus / Copper / Disulfides / Ions Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 2018 Document type: Article

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