The association between vitamin D status and tuberculosis in children: A meta-analysis.
Medicine (Baltimore)
; 97(35): e12179, 2018 Aug.
Article
in En
| MEDLINE
| ID: mdl-30170465
ABSTRACT
BACKGROUND:
Vitamin D deficiency (VDD) has been implicated in the pathogenesis of tuberculosis (TB), but most studies have not reported a significant association. We conducted a meta-analysis to explore the association between vitamin D status and TB in children.METHODS:
Web of Science, Ovid Medline, and EMBASE were searched for studies in English that discussed vitamin D status and TB in children before January 22, 2018.RESULTS:
From the 585 initially identified studies, we selected those that addressed an association between vitamin D status and TB according to our preselected inclusion criteria. Our meta-analysis included 10 studies. According to the random effects model, TB was significantly associated with VDD (ORs, 1.70; 95% CI, 1.20-2.42; Pâ<â.05) in children. Vitamin D levels were significantly lower in TB patients than in controls, with a mean difference dâ=â-5.49ânmol/L (95% CI, -10.42 to -0.55; Pâ<â.05), indicating that VDD was significantly associated with TB (OR, 1.78; 95% CI, 1.30-2.44; Pâ<â.05) in children.CONCLUSION:
This study suggests that vitamin D levels are significantly lower in children with TB/latent TB infection than in controls. TB may contribute to VDD in children. Therefore, VDD may be associated with TB in children.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis, Pulmonary
/
Vitamin D
/
Vitamin D Deficiency
/
Latent Tuberculosis
Type of study:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Medicine (Baltimore)
Year:
2018
Document type:
Article
Affiliation country:
China