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MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges.
Mansouri, Alireza; Hachem, Laureen D; Mansouri, Sheila; Nassiri, Farshad; Laperriere, Normand J; Xia, Daniel; Lindeman, Neal I; Wen, Patrick Y; Chakravarti, Arnab; Mehta, Minesh P; Hegi, Monika E; Stupp, Roger; Aldape, Kenneth D; Zadeh, Gelareh.
Affiliation
  • Mansouri A; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Hachem LD; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Mansouri S; MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Nassiri F; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Laperriere NJ; MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Xia D; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Lindeman NI; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Wen PY; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Chakravarti A; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Mehta MP; Radiation Oncology, The Ohio State University College of Medicine, Columbus, Ohio, USA.
  • Hegi ME; Department of Radiation Oncology, Miami Cancer Institute, Miami, Florida, USA.
  • Stupp R; Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland.
  • Aldape KD; Malnati Brain Tumor Institute of the Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Zadeh G; Department of Laboratory Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Neuro Oncol ; 21(2): 167-178, 2019 02 14.
Article in En | MEDLINE | ID: mdl-30189035
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Modification Methylases / Gene Expression Regulation, Neoplastic / Promoter Regions, Genetic / Glioblastoma / DNA Methylation / Tumor Suppressor Proteins / DNA Repair Enzymes Type of study: Prognostic_studies Limits: Humans Language: En Journal: Neuro Oncol Journal subject: NEOPLASIAS / NEUROLOGIA Year: 2019 Document type: Article Affiliation country: Canada Country of publication: United kingdom
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Modification Methylases / Gene Expression Regulation, Neoplastic / Promoter Regions, Genetic / Glioblastoma / DNA Methylation / Tumor Suppressor Proteins / DNA Repair Enzymes Type of study: Prognostic_studies Limits: Humans Language: En Journal: Neuro Oncol Journal subject: NEOPLASIAS / NEUROLOGIA Year: 2019 Document type: Article Affiliation country: Canada Country of publication: United kingdom