The risk factors of linezolid-induced lactic acidosis: A case report and review.
Medicine (Baltimore)
; 97(36): e12114, 2018 Sep.
Article
in En
| MEDLINE
| ID: mdl-30200095
ABSTRACT
BACKGROUND:
In recent years, linezolid is increasingly used in multidrug-resistant bacteria therapy. At the same time, linezolid-induced lactic acidosis has been continually reported as a serious side effect. Notably, to our knowledge, there are limited available literatures that evaluate risk factors for linezolid-induced lactic acidosis, and there is no highly reliable study on the relationship between linezolid-induced lactic acidosis and age or gender. However, clinicians need relevant information to advice on the use of linezolid. Therefore, we report on a case of life-threatening lactic acidosis after 3 doses of linezolid exposure and evaluate the risk factors of linezolid-induced lactic acidosis.METHODS:
Cases of linezolid-induced lactic acidosis reported in PubMed were searched. Several characteristics and data of case numbers and deaths were extracted for analysis.RESULTS:
A total of 35 articles including 47 cases were included in this study. Twelve patients (25.5%) died due to linezolid-induced lactic acidosis. At the cut-offs of 7, 14, and 28 days, the mortalities were 27.3%, 20%, and 27.3%. No statistically significant difference was observed according to age and gender. However, the proportion (27.7% and 29.8%) and mortality (30.8% and 35.7%) of male patients were much higher than females in both ≥65 and <65 years old groups (proportion 15.2% and 23.9%; mortality 14.3% and 18.2%).CONCLUSION:
The mortality of linezolid-induced lactic acidosis was relatively high. The duration of linezolid use and age might not be risk factors. Gender (specifically, male) might be related to the mortality of linezolid-induced lactic acidosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acidosis, Lactic
/
Linezolid
/
Anti-Bacterial Agents
Type of study:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Medicine (Baltimore)
Year:
2018
Document type:
Article
Affiliation country:
China