The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP.

Shiozaki, Yuji; Okamura, Kayo; Kohno, Shohei; Keenan, Audrey L; Williams, Kristina; Zhao, Xiaoyun; Chick, Wallace S; Miyazaki-Anzai, Shinobu; Miyazaki, Makoto

Shiozaki, Yuji; Okamura, Kayo; Kohno, Shohei; Keenan, Audrey L; Williams, Kristina; Zhao, Xiaoyun; Chick, Wallace S; Miyazaki-Anzai, Shinobu; Miyazaki, Makoto.

Affiliation

Shiozaki Y; From the Division of Renal Diseases and Hypertension, Department of Medicine, and.
Okamura K; From the Division of Renal Diseases and Hypertension, Department of Medicine, and.
Kohno S; From the Division of Renal Diseases and Hypertension, Department of Medicine, and.
Keenan AL; From the Division of Renal Diseases and Hypertension, Department of Medicine, and.
Williams K; the Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, Colorado 80045.
Zhao X; the Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, Colorado 80045.
Chick WS; the Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, Colorado 80045.
Miyazaki-Anzai S; From the Division of Renal Diseases and Hypertension, Department of Medicine, and.
Miyazaki M; From the Division of Renal Diseases and Hypertension, Department of Medicine, and makoto.miyazaki@ucdenver.edu.

J Biol Chem ; 293(44): 17008-17020, 2018 11 02.

Article in En | MEDLINE | ID: mdl-30209133

Subject(s)

Cyclin T/metabolism; Cyclin-Dependent Kinase 9/metabolism; Fatty Acids/metabolism; Renal Insufficiency, Chronic/complications; Transcription Factor CHOP/genetics; Vascular Calcification/metabolism; Activating Transcription Factor 4/genetics; Activating Transcription Factor 4/metabolism; Animals; Cyclin T/genetics; Cyclin-Dependent Kinase 9/genetics; Endoplasmic Reticulum Stress; Humans; Male; Mice; Mice, Inbred DBA; Mice, Transgenic; Myocytes, Smooth Muscle/metabolism; Phosphorylation; Protein Binding; Renal Insufficiency, Chronic/genetics; Renal Insufficiency, Chronic/metabolism; Renal Insufficiency, Chronic/physiopathology; Transcription Factor CHOP/metabolism; Vascular Calcification/etiology; Vascular Calcification/genetics; Vascular Calcification/physiopathology

Key words

CDK9; CHOP; ER stress; atherosclerosis; cardiovascular disease; cyclin-dependent kinase (CDK); endoplasmic reticulum stress (ER stress); fatty acid; kidney disease; renal dysfunction; saturated fatty acids; vascular biology; vascular calcification; vascular smooth muscle cells

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclin-Dependent Kinase 9 / Renal Insufficiency, Chronic / Transcription Factor CHOP / Fatty Acids / Cyclin T / Vascular Calcification Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Biol Chem Year: 2018 Document type: Article Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google