Nestin Expression in Spitzoid Lesions: An Immunohistochemical Characterization With Clinical and Dermoscopic Correlations.
Appl Immunohistochem Mol Morphol
; 27(6): 430-435, 2019 07.
Article
in En
| MEDLINE
| ID: mdl-30212379
ABSTRACT
Spindle or epithelioid melanocytic (Spitz) nevi usually affect children or adolescents and growth in the face or the lower extremities. Histologically, they may show cytoarchitectural atypia and mitotic figures that could represent diagnostic pitfalls with malignant melanoma. Atypical spitzoid tumors (AST) indicate lesions that microscopically show intermediate characteristics between benign nevi and malignant melanoma. Nestin expression has been evaluated in benign nevi and malignant melanoma, but no studies on its role in Spitz lesion have been elaborated so far. Our results indicate that Nestin could allow to discriminate between AST and malignant spiztoid melanoma; the typical dermoscopic pattern is also associated with benign nevi in contrast to the atypical pattern that accumunates AST and malignant spitzoid melanoma.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
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Nevus, Epithelioid and Spindle Cell
/
Dermis
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Nestin
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Melanoma
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
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Infant
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Male
/
Middle aged
Language:
En
Journal:
Appl Immunohistochem Mol Morphol
Journal subject:
BIOLOGIA MOLECULAR
/
HISTOCITOQUIMICA
Year:
2019
Document type:
Article