Evidence for a differential visual M300 brain response in gamblers.
Clin Neurophysiol
; 129(11): 2228-2238, 2018 11.
Article
in En
| MEDLINE
| ID: mdl-30216906
ABSTRACT
OBJECTIVE:
Gambling disorder is the first behavioral addiction recognized in the DSM-5. This marks the growing realization that both behavioral and substance-related addictions are manifestations of an 'addicted brain', displaying similar altered neurophysiological mechanisms. A decreased electrophysiological visual P300 is considered a hallmark effect of substance-related addictions, but has not yet been shown in behavioral addictions.METHODS:
Magnetoencephalographic recordings of 15 gamblers and 17 controls were taken as they performed a cue-reactivity paradigm in which they passively viewed addiction- and non-addiction-related cues.RESULTS:
The main finding of the study is a reduction in the magnetic counterpart of P300 (M300) for gamblers beyond cue condition over frontal regions. Additionally, we found a significant group by cue-type interaction. Gamblers exhibited heightened sensitivity to addiction-related cues in regions corresponding to the frontoparietal attentional network, whereas controls exhibited an opposite effect localized to the right insula.CONCLUSIONS:
The results suggest that a reduced P300 characterizes addictions in general, not just substance-related addictions, thus providing important neurophysiological support for the inclusion of behavioral addictions in the DSM-5 and in the incentive-sensitization theory.SIGNIFICANCE:
The study offers important insights into neural mechanisms underlying behavioral addictions, and may assist in developing better prevention and intervention strategies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Event-Related Potentials, P300
/
Evoked Potentials, Visual
/
Sensorimotor Cortex
/
Gambling
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Neurophysiol
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Israel