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In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.
Vaupel, Andrea; Holzer, Philipp; Ferretti, Stephane; Guagnano, Vito; Kallen, Joerg; Mah, Robert; Masuya, Keiichi; Ruetz, Stephan; Rynn, Caroline; Schlapbach, Achim; Stachyra, Thérèse; Stutz, Stefan; Todorov, Milen; Jeay, Sébastien; Furet, Pascal.
Affiliation
  • Vaupel A; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland. Electronic address: andrea.vaupel@novartis.com.
  • Holzer P; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Ferretti S; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Guagnano V; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Kallen J; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Mah R; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Masuya K; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Ruetz S; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Rynn C; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Schlapbach A; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Stachyra T; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Stutz S; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Todorov M; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Jeay S; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Furet P; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
Bioorg Med Chem Lett ; 28(20): 3404-3408, 2018 11 01.
Article in En | MEDLINE | ID: mdl-30217415
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrrolidinones / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Protein Multimerization / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrrolidinones / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Protein Multimerization / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Country of publication: United kingdom