ADHD-originating in the gut? The emergence of a new explanatory model.
Med Hypotheses
; 120: 135-145, 2018 Nov.
Article
in En
| MEDLINE
| ID: mdl-30220333
ABSTRACT
The microbiome-gut-brain axis paradigm explains that alterations in the central nervous system and behavior may be secondary to functional changes in the gut in general and more specifically the enteric nervous system. An unfavorable development of the intestinal microbial ecosystem, leading to e.g. a diminished microbial diversity, may play a central role. This paper outlines, and describes the theoretical basis of, a novel integrative model explaining the etiology and pathogenesis of ADHD in a microbiota-gut-brain context, taking into account the complexity of the bi-directional signaling between the gut and the brain.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Enteric Nervous System
/
Immune System
Limits:
Animals
/
Humans
Language:
En
Journal:
Med Hypotheses
Year:
2018
Document type:
Article
Affiliation country:
Sweden