The relationship between the serotonin 2A receptor gene -1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patients.
Hum Psychopharmacol
; 33(5): e2673, 2018 09.
Article
in En
| MEDLINE
| ID: mdl-30221791
ABSTRACT
OBJECTIVE:
The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder.METHODS:
A total of 128 patients were enrolled, 63 patients received CIT, whereas 65 patients were treated with SERT. Nausea/vomiting were assessed with the UKU Side-effects Rating Scale at baseline and at the end of the second and fourth weeks. Polymerase chain reaction-restriction fragment length polymorphism technique was employed to determine genetic differences.RESULTS:
We have found that, in the patients treated with CIT, there was a nominally significant difference in the genotypic distribution associated with -1438A/G polymorphism between patients with and without nausea (X2 = 6.15, p = 0.041). Moreover, logistic regression analysis revealed a significant association between nausea/vomiting as a side effect and -1438A/G polymorphism. That is, patients with the G allele were at a higher risk for developing nausea/vomiting (p = 0.044, odds ratio = 2.213). The 102T/C polymorphism in the HTR2A gene had no significant effect on the nausea/vomiting as a side effect among participants treated with either CIT or SERT.CONCLUSION:
The present study suggests the association of the HTR2A gene -1438A/G polymorphism with nausea/vomiting as a side effect related to CIT treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vomiting
/
Citalopram
/
Sertraline
/
Receptor, Serotonin, 5-HT2A
/
Nausea
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Hum Psychopharmacol
Journal subject:
PSICOFARMACOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Turkey