Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels.
Data Brief
; 20: 1105-1114, 2018 Oct.
Article
in En
| MEDLINE
| ID: mdl-30225325
ABSTRACT
As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Data Brief
Year:
2018
Document type:
Article
Affiliation country:
United States