Your browser doesn't support javascript.
loading
RNA interference to enhance radiation therapy: Targeting the DNA damage response.
Ratnayake, G; Bain, A L; Fletcher, N; Howard, C B; Khanna, K K; Thurecht, K J.
Affiliation
  • Ratnayake G; Centre of Advanced Imaging, University of Queensland, Australia; Australian Institute of Bioengineering and Nanotechnology, University of Queensland, Australia; QIMR Berghofer Medical Research Institute, Australia; Royal Brisbane and Women's Hospital, Australia. Electronic address: gishan.ratnayake@
  • Bain AL; QIMR Berghofer Medical Research Institute, Australia.
  • Fletcher N; Centre of Advanced Imaging, University of Queensland, Australia; Australian Institute of Bioengineering and Nanotechnology, University of Queensland, Australia.
  • Howard CB; Centre of Advanced Imaging, University of Queensland, Australia; Australian Institute of Bioengineering and Nanotechnology, University of Queensland, Australia.
  • Khanna KK; QIMR Berghofer Medical Research Institute, Australia.
  • Thurecht KJ; Centre of Advanced Imaging, University of Queensland, Australia; Australian Institute of Bioengineering and Nanotechnology, University of Queensland, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.
Cancer Lett ; 439: 14-23, 2018 12 28.
Article in En | MEDLINE | ID: mdl-30240587
ABSTRACT
RNA interference (RNAi) therapy is an emerging class of biopharmaceutical that has immense potential in cancer medicine. RNAi medicines are based on synthetic oligonucleotides that can suppress a target protein in tumour cells with high specificity. This review explores the attractive prospect of using RNAi as a radiosensitiser by targeting the DNA damage response. There are a multitude of molecular targets involved in the detection and repair of DNA damage that are suitable for this purpose. Recent developments in delivery technologies such nanoparticle carriers and conjugation strategies have allowed RNAi therapeutics to enter clinical trials in the treatment of cancer. With further progress, RNAi targeting of the DNA damage response may hold great promise in guiding radiation oncology into the era of precision medicine.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Tolerance / DNA Damage / RNA Interference / Neoplasms Limits: Humans Language: En Journal: Cancer Lett Year: 2018 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Tolerance / DNA Damage / RNA Interference / Neoplasms Limits: Humans Language: En Journal: Cancer Lett Year: 2018 Document type: Article