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Discovery of a small molecule modulator of the Kv1.1/Kvß1 channel complex that reduces neuronal excitability and in vitro epileptiform activity.
Niespodziany, Isabelle; Mullier, Brice; André, Véronique Marie; Ghisdal, Philippe; Jnoff, Eric; Moreno-Delgado, David; Swinnen, Dominique; Sands, Zara; Wood, Martyn; Wolff, Christian.
Affiliation
  • Niespodziany I; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • Mullier B; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • André VM; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • Ghisdal P; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • Jnoff E; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • Moreno-Delgado D; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • Swinnen D; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • Sands Z; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • Wood M; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
  • Wolff C; Department of Neuroscience Research, UCB Pharma, Braine l'Alleud, Belgium.
CNS Neurosci Ther ; 25(4): 442-451, 2019 04.
Article in En | MEDLINE | ID: mdl-30242974
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Action Potentials / Kv1.1 Potassium Channel / Drug Discovery / Hippocampus / Neurons Limits: Animals / Female / Humans Language: En Journal: CNS Neurosci Ther Journal subject: NEUROLOGIA / TERAPEUTICA Year: 2019 Document type: Article Affiliation country: Belgium Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Action Potentials / Kv1.1 Potassium Channel / Drug Discovery / Hippocampus / Neurons Limits: Animals / Female / Humans Language: En Journal: CNS Neurosci Ther Journal subject: NEUROLOGIA / TERAPEUTICA Year: 2019 Document type: Article Affiliation country: Belgium Country of publication: United kingdom