A liposome preparation based on ß-CD-LPC molecule and its application as drug-delivery system.
Nanomedicine (Lond)
; 13(21): 2777-2789, 2018 11.
Article
in En
| MEDLINE
| ID: mdl-30247090
ABSTRACT
AIM:
The ß-CD-LPC molecule was synthesized based on the conjugation of LPC and ß-CD molecules and it could self-assemble into liposome which was used to encapsulate the Dox to form nanomedicine for the cancer therapy. MATERIALS &METHODS:
The anticancer and antitumor effect of ß-CD-LPC-Dox nanomedicine was studied with the vitro and vivo experimental methods.RESULTS:
The result showed that ß-CD-LPC liposome had high Dox drug-loading rate and a good sustained-release effect. Cell experiment showed that the ß-CD-LPC-Dox nanomedicine could effectively induce cancer cell apoptosis and in vivo experiments showed that ß-CD-LPC-Dox liposome could effectively inhibit tumor growth and had an effective anticancer activity with lower biotoxicity.CONCLUSION:
The ß-CD-LPC-Dox nanomedicine could be applied as a candidate drug to therapy the cancer.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Doxorubicin
/
Drug Delivery Systems
/
Beta-Cyclodextrins
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Nanomedicine (Lond)
Year:
2018
Document type:
Article