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Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus.
da Costa, Antônio Charlys; Luchs, Adriana; Milagres, Flávio Augusto de Pádua; Komninakis, Shirley Vasconcelos; Gill, Danielle Elise; Lobato, Márcia Cristina Alves Brito Sayão; Brustulin, Rafael; das Chagas, Rogério Togisaki; Abrão, Maria de Fátima Neves Dos Santos; Soares, Cassia Vitória de Deus Alves; Deng, Xutao; Sabino, Ester Cerdeira; Delwart, Eric; Leal, Élcio.
Affiliation
  • da Costa AC; Institute of Tropical Medicine, University of São Paulo, São Paulo 05403-000, Brazil. charlysbr@yahoo.com.br.
  • Luchs A; Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo 01246-000, Brazil. driluchs@gmail.com.
  • Milagres FAP; LIM/46, Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil. flaviomilagres@uft.edu.br.
  • Komninakis SV; Secretary of Health of Tocantins, Tocantins 77453-000, Brazil. flaviomilagres@uft.edu.br.
  • Gill DE; Institute of Biological Sciences, Federal University of Tocantins, Tocantins 77001-090, Brazil. flaviomilagres@uft.edu.br.
  • Lobato MCABS; Public Health Laboratory of Tocantins State (LACEN/TO), Tocantins 77016-330, Brazil. flaviomilagres@uft.edu.br.
  • Brustulin R; Postgraduate Program in Health Science, Faculty of Medicine of ABC, Santo André 09060-870, Brazil. skomninakis@yahoo.com.br.
  • das Chagas RT; Retrovirology Laboratory, Federal University of São Paulo, São Paulo 04023-062, Brazil. skomninakis@yahoo.com.br.
  • Abrão MFNDS; Institute of Tropical Medicine, University of São Paulo, São Paulo 05403-000, Brazil. degill@g.clemson.edu.
  • Soares CVDA; Secretary of Health of Tocantins, Tocantins 77453-000, Brazil. eumarciaalvesbrito@gmail.com.
  • Deng X; Public Health Laboratory of Tocantins State (LACEN/TO), Tocantins 77016-330, Brazil. eumarciaalvesbrito@gmail.com.
  • Sabino EC; Secretary of Health of Tocantins, Tocantins 77453-000, Brazil. eu3rafael@gmail.com.
  • Delwart E; Institute of Biological Sciences, Federal University of Tocantins, Tocantins 77001-090, Brazil. eu3rafael@gmail.com.
  • Leal É; Public Health Laboratory of Tocantins State (LACEN/TO), Tocantins 77016-330, Brazil. eu3rafael@gmail.com.
Viruses ; 10(10)2018 09 24.
Article in En | MEDLINE | ID: mdl-30249971
ABSTRACT
Here we report the nearly full-length genome of a recombinant Saffold virus strain (SAFV-BR-193) isolated from a child with acute gastroenteritis. Evolutionary analysis performed using all available near-full length Saffold picornavirus genomes showed that the breakpoint found in the Brazilian strain (SAFV-BR-193) is indeed a recombination hotspot. Notably, this hotspot is located just one nucleotide after the ribosomal frameshift GGUUUUU motif in the SAFV genome. Empirical studies will be necessary to determine if this motif also affects the binding affinity of RNA-dependent RNA-polymerase (RdRp) and therefore increases the changes of RdRp swap between molecules during the synthesis of viral genomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombination, Genetic / Cardiovirus Infections / Cardiovirus / Frameshifting, Ribosomal / Gastroenteritis Limits: Child, preschool / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Viruses Year: 2018 Document type: Article Affiliation country: Brazil
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombination, Genetic / Cardiovirus Infections / Cardiovirus / Frameshifting, Ribosomal / Gastroenteritis Limits: Child, preschool / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Viruses Year: 2018 Document type: Article Affiliation country: Brazil