The influence of lifestyle, diet, and reproductive history on age at natural menopause in Spain: Analysis from the EPIC-Spain sub-cohort.
Am J Hum Biol
; 30(6): e23181, 2018 11.
Article
in En
| MEDLINE
| ID: mdl-30251288
ABSTRACT
OBJECTIVE:
To determinate the role of lifestyle factors, recent diet, menstrual factors, and reproductive history in age at natural menopause in adult Spanish women.METHODS:
In total, 12 562 pre-menopausal women were available for analysis from the EPIC-Spain sub-cohort. Women were recruited between 1992 and 1996 in five regions of Spain (Asturias, Granada, Murcia, Navarra, and San Sebastian) and, for these analyses, were followed for 3 years. Questionnaires on diet, lifestyle, anthropometric measurements, and reproductive and exogenous hormones history were collected at baseline. Menopause status was updated at a median of 3 years of follow-up.RESULTS:
After a median of 3 years of follow-up 1166 women became postmenopausal. An earlier age at menopause was observed in current smokers (HR 1.29; 95%CI 1.08-1.55) and in non-users of oral contraceptives (HR 1.32; 95%CI 1.01-1.57). A later age at menopause was observed in women with irregular menses (HR 0.71; 95%CI 0.56-0.91) and in women with a higher number of pregnancies (HR 0.74; 95%CI 0.56-0.94).CONCLUSIONS:
Our results confirm that women who smoked had an earlier age at natural menopause, while use of oral contraceptives, higher number of pregnancies, and irregularity of menses were associated with a prolonged reproductive lifespan. No associations were observed for dietary habits assessed after the age of 40 years.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Menopause
/
Reproductive History
/
Diet
/
Life Style
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Am J Hum Biol
Journal subject:
BIOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Spain