Epidemiology of gastroschisis: A population-based study in California from 1995 to 2012.
J Pediatr Surg
; 53(12): 2399-2403, 2018 Dec.
Article
in En
| MEDLINE
| ID: mdl-30266482
ABSTRACT
BACKGROUND:
Although the incidence of gastroschisis is increasing, risk factors are not clearly identified.METHODS:
Using the Linked Birth Database from the California Office of Statewide Health Planning and Development from 1995 to 2012, patients with gastroschisis were identified by ICD-9 diagnosis/procedure code or birth certificate designation. Logistic regressions examined demographics, birth factors, and maternal exposures on risk of gastroschisis.RESULTS:
The prevalence of gastroschisis was 2.7 cases per 10,000 live births. Patients with gastroschisis had no difference in fetal exposure to alcohol (pâ¯=â¯0.609), narcotics (pâ¯=â¯0.072), hallucinogenics (pâ¯=â¯0.239), or cocaine (pâ¯=â¯0.777), but had higher exposure to unspecified/other noxious substances (OR 3.27, pâ¯=â¯0.040; OR 2.02, pâ¯=â¯0.002). Gastroschisis was associated with low/very low birthweight (OR 5.08-16.21, pâ¯<â¯0.001) and preterm birth (OR 3.26-10.0, pâ¯<â¯0.001). Multivariable analysis showed lower risk in black (OR 0.44, pâ¯<â¯0.001), Asian/Pacific Islander (OR 0.76, pâ¯=â¯0.003), and Hispanic patients (OR 0.72, pâ¯<â¯0.001) compared to white patients. Risk was higher in rural areas (OR 1.24-1.76, pâ¯=â¯0.001). Compared to women ageâ¯<â¯20, risk decreased with advancing maternal age (OR 0.49-OR 0.03, pâ¯<â¯0.001). Patients with gastroschisis had increased total charges ($336,270 vs. $9012, pâ¯<â¯0.001) and length of stay (38.1 vs. 2.9â¯days, pâ¯<â¯0.001). Mortality was 4.6%.CONCLUSIONS:
This is the largest population-based study summarizing current epidemiology of gastroschisis in California. TYPE OF STUDY Retrospective comparative cohort study. LEVEL OF EVIDENCE III.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prenatal Exposure Delayed Effects
/
Gastroschisis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Country/Region as subject:
America do norte
Language:
En
Journal:
J Pediatr Surg
Year:
2018
Document type:
Article