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Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.
Xu, Guozhang; Gaul, Michael D; Kuo, Gee-Hong; Du, Fuyong; Xu, June Zhi; Wallace, Nathaniel; Hinke, Simon; Kirchner, Thomas; Silva, Jose; Huebert, Norman D; Lee, Seunghun; Murray, William; Liang, Yin; Demarest, Keith.
Affiliation
  • Xu G; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA. Electronic address: gxu4@its.jnj.com.
  • Gaul MD; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Kuo GH; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Du F; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Xu JZ; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Wallace N; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Hinke S; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Kirchner T; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Silva J; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Huebert ND; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Lee S; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Murray W; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Liang Y; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
  • Demarest K; Discovery Sciences and Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Bioorg Med Chem Lett ; 28(21): 3446-3453, 2018 11 15.
Article in En | MEDLINE | ID: mdl-30268701
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Deoxyglucose / Diabetes Mellitus, Experimental / Sodium-Glucose Transporter 1 / Sodium-Glucose Transporter 2 Inhibitors / Hypoglycemic Agents Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Deoxyglucose / Diabetes Mellitus, Experimental / Sodium-Glucose Transporter 1 / Sodium-Glucose Transporter 2 Inhibitors / Hypoglycemic Agents Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Country of publication: United kingdom