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PET imaging of [11C]PBR28 in Parkinson's disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding.
Varnäs, Katarina; Cselényi, Zsolt; Jucaite, Aurelija; Halldin, Christer; Svenningsson, Per; Farde, Lars; Varrone, Andrea.
Affiliation
  • Varnäs K; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, R5:02 Karolinska University Hospital, SE-17176, Stockholm, Sweden. katarina.varnas@ki.se.
  • Cselényi Z; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, R5:02 Karolinska University Hospital, SE-17176, Stockholm, Sweden.
  • Jucaite A; PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, Stockholm, Sweden.
  • Halldin C; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, R5:02 Karolinska University Hospital, SE-17176, Stockholm, Sweden.
  • Svenningsson P; PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, Stockholm, Sweden.
  • Farde L; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, R5:02 Karolinska University Hospital, SE-17176, Stockholm, Sweden.
  • Varrone A; Department of Clinical Neuroscience, Translational Neuropharmacology, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Eur J Nucl Med Mol Imaging ; 46(2): 367-375, 2019 02.
Article in En | MEDLINE | ID: mdl-30270409
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Pyrimidines / Receptors, GABA / Positron-Emission Tomography / Dopamine Plasma Membrane Transport Proteins Type of study: Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Nucl Med Mol Imaging Journal subject: MEDICINA NUCLEAR Year: 2019 Document type: Article Affiliation country: Sweden Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Pyrimidines / Receptors, GABA / Positron-Emission Tomography / Dopamine Plasma Membrane Transport Proteins Type of study: Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Nucl Med Mol Imaging Journal subject: MEDICINA NUCLEAR Year: 2019 Document type: Article Affiliation country: Sweden Country of publication: Germany