DNA repair defects in prostate cancer: impact for screening, prognostication and treatment.

Warner, Evan W; Yip, Steven M; Chi, Kim N; Wyatt, Alexander W

Warner, Evan W; Yip, Steven M; Chi, Kim N; Wyatt, Alexander W.

Affiliation

Warner EW; Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Yip SM; Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.
Chi KN; Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.
Wyatt AW; Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

BJU Int ; 123(5): 769-776, 2019 05.

Article in En | MEDLINE | ID: mdl-30281887

Subject(s)

DNA Mutational Analysis; DNA Repair; Early Detection of Cancer/methods; Prostatic Neoplasms, Castration-Resistant/diagnosis; Prostatic Neoplasms, Castration-Resistant/genetics; Androgen Antagonists/therapeutic use; BRCA2 Protein; Biomarkers, Tumor; Circulating Tumor DNA; DNA Repair/drug effects; Humans; Male; Predictive Value of Tests; Prognosis; Prostatic Neoplasms, Castration-Resistant/drug therapy; Prostatic Neoplasms, Castration-Resistant/pathology

Key words

#PCSM; BRCA2; PARP inhibitors; circulating tumour DNA; homologous recombination; metastasis; mismatch repair

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Mutational Analysis / DNA Repair / Early Detection of Cancer / Prostatic Neoplasms, Castration-Resistant Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Humans / Male Language: En Journal: BJU Int Journal subject: UROLOGIA Year: 2019 Document type: Article Affiliation country: Canada

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