Association analysis of genetic polymorphisms and expression levels of selected genes involved in extracellular matrix turnover and angiogenesis with the risk of age-related macular degeneration.

Oszajca, Katarzyna; Szemraj, Maciej; Szemraj, Janusz; Jurowski, Piotr

Oszajca, Katarzyna; Szemraj, Maciej; Szemraj, Janusz; Jurowski, Piotr.

Affiliation

Oszajca K; a Department of Medical Biochemistry , Medical University of Lodz , Lodz , Poland.
Szemraj M; b Department of Ophthalmology and Visual Rehabilitation , Central Veterans' Hospital , Lodz , Poland.
Szemraj J; a Department of Medical Biochemistry , Medical University of Lodz , Lodz , Poland.
Jurowski P; b Department of Ophthalmology and Visual Rehabilitation , Central Veterans' Hospital , Lodz , Poland.

Ophthalmic Genet ; 39(6): 684-698, 2018 12.

Article in En | MEDLINE | ID: mdl-30289322

Subject(s)

Extracellular Matrix/enzymology; Macular Degeneration/genetics; Matrix Metalloproteinases/genetics; Polymorphism, Single Nucleotide; Retinal Neovascularization/genetics; Tissue Inhibitor of Metalloproteinase-2/genetics; Vascular Endothelial Growth Factor Receptor-2/genetics; Aged; Aged, 80 and over; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Enzymologic/physiology; Genotyping Techniques; Humans; Macular Degeneration/diagnosis; Macular Degeneration/enzymology; Male; Matrix Metalloproteinase 2/blood; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 7/blood; Matrix Metalloproteinase 7/genetics; Matrix Metalloproteinase 9/blood; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinases/blood; Middle Aged; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Retinal Neovascularization/diagnosis; Retinal Neovascularization/enzymology; Tissue Inhibitor of Metalloproteinase-2/blood; Vascular Endothelial Growth Factor A/blood; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor Receptor-2/blood

Key words

age-related macular degeneration; metalloproteinase; single nucleotide polymorphism; vascular endothelial growth factor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Neovascularization / Tissue Inhibitor of Metalloproteinase-2 / Matrix Metalloproteinases / Polymorphism, Single Nucleotide / Vascular Endothelial Growth Factor Receptor-2 / Extracellular Matrix / Macular Degeneration Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Ophthalmic Genet Journal subject: GENETICA MEDICA / OFTALMOLOGIA Year: 2018 Document type: Article Affiliation country: Poland Country of publication: United kingdom

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