A retrospective, population-based cohort study of driving under the influence, Alzheimer's disease diagnosis, and survival.
Int Psychogeriatr
; 31(4): 571-577, 2019 04.
Article
in En
| MEDLINE
| ID: mdl-30303050
ABSTRACT
ABSTRACTIntroduction:
The relationship between Alzheimer's Disease (AD) and alcohol addiction is poorly characterized. Arrests for driving under the influence (DUI) can serve as a proxy for alcohol addiction. Therefore, the potential association between DUI and AD could be helpful in understanding the relationship between alcohol abuse and AD. MATERIALS ANDMETHODS:
A retrospective, population-based cohort study using state health and law enforcement data was performed. The study cross-referenced 141,281 South Carolina Alzheimer's Disease Registry cases with state law enforcement data.RESULTS:
Of the 2,882 registry cases (1.4%) found to have a history of at least one DUI arrest, cases were predominantly White (58.7%) and male (77.4%). Results showed a correlation coefficient of 0.7 (p < 0.0001) between the age of first DUI arrest and the age of AD diagnosis. A dose-response relationship between the number of DUIs and age of AD onset was found to exist, where those with a history of DUI arrest were diagnosed an average of 9.1 years earlier, with a further 1.8 years earlier age at diagnosis in those with two or more arrests for DUI. A history of DUI arrest was also found to be negatively associated with survival after diagnosis, with a 10% decreased life expectancy in those with a DUI arrest history.CONCLUSIONS:
Driving under the influence, a potential indicator of alcohol addiction, is associated with an earlier onset of AD registry diagnosis and shortened survival after diagnosis. This study contributes to the growing body of evidence suggesting that some cases of AD are alcohol related and, possibly, postponable or preventable.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alcoholism
/
Alzheimer Disease
/
Driving Under the Influence
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
America do norte
Language:
En
Journal:
Int Psychogeriatr
Journal subject:
GERIATRIA
/
PSIQUIATRIA
Year:
2019
Document type:
Article
Affiliation country:
United States