Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment.
Front Immunol
; 9: 2259, 2018.
Article
in En
| MEDLINE
| ID: mdl-30323819
ABSTRACT
The neonatal Fc receptor (FcRn) is responsible for the recycling and transcytosis of IgG and albumin. FcRn level was found altered in cancer tissues and implicated in tumor immunosurveillance and neoplastic cell growth. However, the consequences of FcRn down-regulation in the anti-tumor immune response are not fully elucidated. By using the B16F10 experimental lung metastasis model in an FcRn-deficient microenvironment (FcRn-/- mice), we found lung metastasis associated with an abnormal natural killer (NK) cell phenotype. In FcRn-/- mice, NK cells were immature, as shown by their surface marker profile and their decreased ability to degranulate and synthesize interferon γ after chemical and IL-2 or IL-12, IL-15 and IL-18 activation. These new findings support the critical role of FcRn downregulation in the tumor microenvironment in anti-tumor immunity, via NK cell maturation and activation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Killer Cells, Natural
/
Receptors, Fc
/
Histocompatibility Antigens Class I
/
Tumor Microenvironment
/
Lung Neoplasms
/
Neoplasm Metastasis
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Front Immunol
Year:
2018
Document type:
Article
Affiliation country:
France