Meta-analysis of the association of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer.
Neoplasma
; 65(6): 855-864, 2018 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-30334445
ABSTRACT
The aim of this study is to comprehensively evaluate the associations of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer (CRC). We searched the English and Chinese databases and recruited case-control studies based on strict inclusion and exclusion criteria. The statistical analysis was performed by the Comprehensive Meta-analysis 2.0 (CMA 2.0) software and this initially identified 251 studies. We then recruited 10 English studies to this meta-analysis detailed review which includes 9,415 CRC patients and 14,179 healthy controls. Our results demonstrated that IGFBP3 rs2854746 C>G polymorphism increases susceptibility to the CRC (allele model OR=1.167, 95% CI=1.095~1.244, p<0.001 and to the dominant gene model OR=1.226, 95% CI=1.113~1.350, p<0.001); but IGFBP3 rs2854744 A>C has no significant association with the CRC susceptibility (allele model OR=0.970, 95% CI=0.932~1.010, p=0.138; dominant gene model OR=0.995, 95% CI=0.936~1.057, p=0.874). Also, IGF1 rs35767 C>T polymorphism decreases susceptibility to CRC (allele model OR=0.785, 95% CI=0.726~0.850, p<0.001 and also the dominant model OR=0.730, 95% CI=0.661~0.806, p<0.001). However, IGFBP3 rs2854746 C>G is considered the susceptible CRC polymorphism and IGF1 rs35767 C>T is CRC protective.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin-Like Growth Factor I
/
Colorectal Neoplasms
/
Insulin-Like Growth Factor Binding Protein 3
/
Genetic Predisposition to Disease
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Neoplasma
Year:
2018
Document type:
Article
Affiliation country:
China