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Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.
Ghosh, Arun K; Jadhav, Ravindra D; Simpson, Hannah; Kovela, Satish; Osswald, Heather; Agniswamy, Johnson; Wang, Yuan-Fang; Hattori, Shin-Ichiro; Weber, Irene T; Mitsuya, Hiroaki.
Affiliation
  • Ghosh AK; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States. Electronic address: akghosh@purdue.edu.
  • Jadhav RD; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Simpson H; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Kovela S; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Osswald H; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Agniswamy J; Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, GA, 30303, United States.
  • Wang YF; Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, GA, 30303, United States.
  • Hattori SI; Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, 162-8655, Japan.
  • Weber IT; Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, GA, 30303, United States.
  • Mitsuya H; Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, 162-8655, Japan; Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto, 860-8556, Japan; Experiment
Eur J Med Chem ; 160: 171-182, 2018 Dec 05.
Article in En | MEDLINE | ID: mdl-30340140
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Drug Design / Chromans / HIV Protease / HIV Protease Inhibitors / Naphthalenes Language: En Journal: Eur J Med Chem Year: 2018 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Drug Design / Chromans / HIV Protease / HIV Protease Inhibitors / Naphthalenes Language: En Journal: Eur J Med Chem Year: 2018 Document type: Article