miR-335-5p induces insulin resistance and pancreatic islet ß-cell secretion in gestational diabetes mellitus mice through VASH1-mediated TGF-ß signaling pathway.

Tang, Xu-Wen; Qin, Qing-Xin

Tang, Xu-Wen; Qin, Qing-Xin.

Affiliation

Tang XW; Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center Affiliated to, Guangzhou Medical University, Guangzhou, China.
Qin QX; Department of Endocrinology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

J Cell Physiol ; 234(5): 6654-6666, 2019 05.

Article in En | MEDLINE | ID: mdl-30341900

Subject(s)

Blood Glucose/genetics; Diabetes, Gestational/genetics; Insulin Resistance/genetics; MicroRNAs/genetics; Transforming Growth Factor beta/deficiency; Animals; Blood Glucose/metabolism; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Female; Glucose Tolerance Test/methods; Insulin/metabolism; Insulin Resistance/physiology; Insulin-Secreting Cells/metabolism; Male; Mice; Pregnancy; Transforming Growth Factor beta/metabolism

Key words

TGF-ß pathway; VASH1; gestational diabetes mellitus; insulin resistance; microRNA-335-5p; pancreatic islet ß-cell secretion

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Insulin Resistance / Transforming Growth Factor beta / Diabetes, Gestational / MicroRNAs Type of study: Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: J Cell Physiol Year: 2019 Document type: Article Affiliation country: China Country of publication: United States

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