First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives.
Molecules
; 23(10)2018 Oct 19.
Article
in En
| MEDLINE
| ID: mdl-30347659
ABSTRACT
Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of ß-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40â»54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1,4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1,4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dihydropyridines
/
Calcium Channel Blockers
/
Catalysis
/
Heterocyclic Compounds
Language:
En
Journal:
Molecules
Journal subject:
BIOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Spain