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Urine concentrations changes of cysteinyl leukotrienes in non-obese children with obstructive sleep apnea undergoing adenotonsillectomy.
Mousailidis, George Κ; Lachanas, Vasileios A; Vasdeki, Afroditi; Alexopoulos, Emmanuel I; Kaditis, Athanasios G; Petinaki, Efthymia; Balatsos, Nikolaos A A; Bizakis, John G; Skoulakis, Charalampos E.
Affiliation
  • Mousailidis GΚ; Department of Otorhinolaryngology, University Hospital of Larissa, Greece.
  • Lachanas VA; Department of Otorhinolaryngology, University Hospital of Larissa, Greece. Electronic address: vlachanas@gmail.com.
  • Vasdeki A; Department of Microbiology, University of Thessaly, University Hospital of Larissa, Greece.
  • Alexopoulos EI; Sleep Disorders Laboratory, University Hospital of Larissa, Greece.
  • Kaditis AG; First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.
  • Petinaki E; Department of Microbiology, University of Thessaly, University Hospital of Larissa, Greece.
  • Balatsos NAA; Department of Biochemistry and Biotechnology, University of Thessaly, Greece.
  • Bizakis JG; Department of Otorhinolaryngology, University Hospital of Larissa, Greece.
  • Skoulakis CE; Department of Otorhinolaryngology, University Hospital of Larissa, Greece.
Int J Pediatr Otorhinolaryngol ; 115: 149-152, 2018 Dec.
Article in En | MEDLINE | ID: mdl-30368376
OBJECTIVE: The main objective of the study was to compare preoperative to postoperative levels of urine-Cysteinyl leukotrienes (uCysLT) in children undergoing adenotonsillectomy (AT) for obstructive sleep apnea (OSA) in order to investigate whether exaggerated leukotriene activity is the cause or consequence of OSA. METHODS AND MATERIALS: A prospective study was conducted on non-obese children (4-10 years old) referred for overnight PSG. Children with moderate/severe OSA treated with AT were included. A second PSG study performed 2 months postoperatively to confirm OSA resolution, and those with residual OSA were excluded. Morning urine specimens after both PSG studies were obtained and pre-operative uCysLT levels were compared to postoperative levels. RESULTS: 27 children fulfilled the criteria and underwent a post-operative PSG study with three exclusions for residual OSA (postop-AHI>2), so the study group consisted of 24 children (mean age: 5.7 ±â€¯2.1 years). Mean preoperative and postoperative AHI was 10.96 ±â€¯5.93 and 1.44 ±â€¯0.56 respectively. Mean preop-uCysLT were 21.14 ±â€¯4.65, while after AT they significantly reduced to 12.62 ±â€¯2.67 (P < 0.01). CONCLUSION: uCysLT levels are significantly reduced after AT in non-obese children with moderate/severe OSA, suggesting that exaggerated leukotriene activity is mainly a consequence of OSA.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urine / Leukotrienes / Sleep Apnea, Obstructive / Cysteine Type of study: Observational_studies Limits: Child / Child, preschool / Female / Humans / Male Language: En Journal: Int J Pediatr Otorhinolaryngol Year: 2018 Document type: Article Affiliation country: Greece Country of publication: Ireland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urine / Leukotrienes / Sleep Apnea, Obstructive / Cysteine Type of study: Observational_studies Limits: Child / Child, preschool / Female / Humans / Male Language: En Journal: Int J Pediatr Otorhinolaryngol Year: 2018 Document type: Article Affiliation country: Greece Country of publication: Ireland