The challenges of peptidomics in complementing proteomics in a clinical context.
Mass Spectrom Rev
; 38(3): 253-264, 2019 05.
Article
in En
| MEDLINE
| ID: mdl-30372792
ABSTRACT
Naturally occurring peptides, including growth factors, hormones, and neurotransmitters, represent an important class of biomolecules and have crucial roles in human physiology. The study of these peptides in clinical samples is therefore as relevant as ever. Compared to more routine proteomics applications in clinical research, peptidomics research questions are more challenging and have special requirements with regard to sample handling, experimental design, and bioinformatics. In this review, we describe the issues that confront peptidomics in a clinical context. After these hurdles are (partially) overcome, peptidomics will be ready for a successful translation into medical practice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Mass Spectrometry
/
Proteomics
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Mass Spectrom Rev
Year:
2019
Document type:
Article
Affiliation country:
Belgium