Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons.

Olenick, Mara A; Dominguez, Roberto; Holzbaur, Erika L F

Olenick, Mara A; Dominguez, Roberto; Holzbaur, Erika L F.

Affiliation

Olenick MA; The Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Dominguez R; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Holzbaur ELF; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA.

J Cell Biol ; 218(1): 220-233, 2019 01 07.

Article in En | MEDLINE | ID: mdl-30373907

Subject(s)

Brain-Derived Neurotrophic Factor/metabolism; Cytoplasmic Dyneins/metabolism; Endosomes/metabolism; Microtubule-Associated Proteins/metabolism; Neurons/metabolism; Receptor, trkB/metabolism; Animals; Axonal Transport; Binding Sites; Brain-Derived Neurotrophic Factor/genetics; Cell Nucleus/metabolism; Cytoplasmic Dyneins/chemistry; Cytoplasmic Dyneins/genetics; Endosomes/ultrastructure; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Hippocampus/metabolism; Hippocampus/ultrastructure; Humans; Luminescent Proteins/genetics; Luminescent Proteins/metabolism; Microtubule-Associated Proteins/chemistry; Microtubule-Associated Proteins/genetics; Models, Molecular; Neurons/ultrastructure; Primary Cell Culture; Protein Binding; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Isoforms/metabolism; Protein Structure, Secondary; Protein Transport; Rats; Rats, Sprague-Dawley; Receptor, trkB/genetics; Signal Transduction; rab5 GTP-Binding Proteins/genetics; rab5 GTP-Binding Proteins/metabolism; Red Fluorescent Protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endosomes / Brain-Derived Neurotrophic Factor / Receptor, trkB / Cytoplasmic Dyneins / Microtubule-Associated Proteins / Neurons Type of study: Prognostic_studies Language: En Journal: J Cell Biol Year: 2019 Document type: Article Country of publication: United States

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