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Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype.
Wang, Bei; Zhang, Wen; Jankovic, Vladimir; Golubov, Jacquelynn; Poon, Patrick; Oswald, Erin M; Gurer, Cagan; Wei, Joyce; Ramos, Ilyssa; Wu, Qi; Waite, Janelle; Ni, Min; Adler, Christina; Wei, Yi; Macdonald, Lynn; Rowlands, Tracey; Brydges, Susannah; Siao, Jean; Poueymirou, William; MacDonald, Douglas; Yancopoulos, George D; Sleeman, Matthew A; Murphy, Andrew J; Skokos, Dimitris.
Affiliation
  • Wang B; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Zhang W; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Jankovic V; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Golubov J; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Poon P; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Oswald EM; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Gurer C; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Wei J; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Ramos I; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Wu Q; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Waite J; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Ni M; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Adler C; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Wei Y; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Macdonald L; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Rowlands T; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Brydges S; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Siao J; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Poueymirou W; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • MacDonald D; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Yancopoulos GD; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Sleeman MA; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Murphy AJ; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA.
  • Skokos D; Regeneron Pharmaceuticals,Tarrytown, New York, NY 10591, USA. dimitris.skokos@regeneron.com.
Sci Immunol ; 3(29)2018 11 02.
Article in En | MEDLINE | ID: mdl-30389797
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Glucocorticoid-Induced TNFR-Related Protein / Programmed Cell Death 1 Receptor / Immunologic Memory / Immunotherapy / Neoplasms Limits: Animals Language: En Journal: Sci Immunol Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Glucocorticoid-Induced TNFR-Related Protein / Programmed Cell Death 1 Receptor / Immunologic Memory / Immunotherapy / Neoplasms Limits: Animals Language: En Journal: Sci Immunol Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States