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Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
Horton, John R; Woodcock, Clayton B; Chen, Qin; Liu, Xu; Zhang, Xing; Shanks, John; Rai, Ganesha; Mott, Bryan T; Jansen, Daniel J; Kales, Stephen C; Henderson, Mark J; Cyr, Matthew; Pohida, Katherine; Hu, Xin; Shah, Pranav; Xu, Xin; Jadhav, Ajit; Maloney, David J; Hall, Matthew D; Simeonov, Anton; Fu, Haian; Vertino, Paula M; Cheng, Xiaodong.
Affiliation
  • Horton JR; Department of Molecular and Cellular Oncology , The University of Texas MD Anderson Cancer Center , Houston , Texas 77030 , United States.
  • Woodcock CB; Department of Biochemistry , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
  • Chen Q; Department of Molecular and Cellular Oncology , The University of Texas MD Anderson Cancer Center , Houston , Texas 77030 , United States.
  • Liu X; Department of Molecular and Cellular Oncology , The University of Texas MD Anderson Cancer Center , Houston , Texas 77030 , United States.
  • Zhang X; Department of Biochemistry , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
  • Shanks J; Department of Molecular and Cellular Oncology , The University of Texas MD Anderson Cancer Center , Houston , Texas 77030 , United States.
  • Rai G; Department of Biochemistry , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
  • Mott BT; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Jansen DJ; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Kales SC; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Henderson MJ; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Cyr M; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Pohida K; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Hu X; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Shah P; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Xu X; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Jadhav A; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Maloney DJ; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Hall MD; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Simeonov A; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
  • Fu H; National Center for Advancing Translational Sciences , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.
J Med Chem ; 61(23): 10588-10601, 2018 12 13.
Article in En | MEDLINE | ID: mdl-30392349
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Enzyme Inhibitors / Retinoblastoma-Binding Protein 2 Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
Print
XML
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Enzyme Inhibitors / Retinoblastoma-Binding Protein 2 Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States