High serum nerve growth factor concentrations are associated with good functional outcome at 3â¯months following acute ischemic stroke.
Clin Chim Acta
; 488: 20-24, 2019 Jan.
Article
in En
| MEDLINE
| ID: mdl-30393197
ABSTRACT
BACKGROUND:
Previous studies in animal model have demonstrated that neurotrophins were associated with functional outcome following stroke. However, the relationship between serum nerve growth factor (NGF) and functional outcome in stroke patients has not been explored. Our objective was to investigate the association between serum NGF concentrations at admission and functional outcome of patients at 3â¯month after stroke.METHODS:
One-hundred eight-five patients with acute ischaemic stroke were recruited in our study. Serum NGF concentrations were measured by ELISA at admission. The stroke severity at admission was assessed by the National Institute of Health Stroke Scale (NIHSS). The modified Rankin Scale (mRS) was used to assess the functional outcome of patients at 3â¯month after stroke. In addition, 100 healthy controls were recruited.RESULTS:
Serum NGF concentrations were higher in good functional outcome group (mRS score of 0-2) than that in poor functional outcome group (mRS score of 3-6) (9.51⯱â¯2.33 vs. 8.12⯱â¯1.61, Pâ¯<â¯0.001). Meanwhile, the serum NGF concentrations in healthy group were lower than that in acute ischemic stroke patients (7.17⯱â¯1.49 vs. 9.15⯱â¯2.24, Pâ¯<â¯0.001). Moreover, our results demonstrated that high serum NGF concentrations (>9.21â¯ng/l) were independently associated with the better functional prognosis at 3â¯months following the occurrence of stroke (OR 0.048, 95% CI 0.012-0.185, Pâ¯<â¯0.001).CONCLUSIONS:
High concentrations of serum NGF at admission may predict good functional outcome of patients at 3â¯months after acute cerebral ischemia stroke.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Ischemia
/
Stroke
/
Nerve Growth Factor
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Chim Acta
Year:
2019
Document type:
Article
Affiliation country:
China