Reduction in Vasa Vasorum Angiogenesis by Lp-PLA2 Selective Inhibitor Through The HIF-1&#945; and VEGF Expression Under Dyslipidemic Conditions in Atherosclerosis Pathogenesis.

Heriansyah, Teuku; Nafisatuzzamrudah, Nafisa; Aini, Fitria N; Ridwan, Muhammad; Primardhika, Rozah F; Wijayanti, Maya; Bekti, Rachmad S; Wihastuti, Titin A

Reduction in Vasa Vasorum Angiogenesis by Lp-PLA2 Selective Inhibitor Through The HIF-1α and VEGF Expression Under Dyslipidemic Conditions in Atherosclerosis Pathogenesis.

Heriansyah, Teuku; Nafisatuzzamrudah, Nafisa; Aini, Fitria N; Ridwan, Muhammad; Primardhika, Rozah F; Wijayanti, Maya; Bekti, Rachmad S; Wihastuti, Titin A.

Affiliation

Heriansyah T; Department of Cardiology, Faculty of Medicine, Syah Kuala University, Banda Aceh, Indonesia.
Nafisatuzzamrudah N; Department of Biomedical, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
Aini FN; Department of Biomedical, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
Ridwan M; Department of Cardiology, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
Primardhika RF; Bachelor Programme, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
Wijayanti M; Bachelor Programme, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
Bekti RS; Departement of Pathology Anatomy of Medicine, Brawijaya University, Malang, Indonesia.
Wihastuti TA; Department of Biomedical, Faculty of Medicine, Brawijaya University, Malang, Indonesia.

Cardiovasc Hematol Agents Med Chem ; 16(2): 114-119, 2018.

Article in En | MEDLINE | ID: mdl-30394217

Subject(s)

1-Alkyl-2-acetylglycerophosphocholine Esterase/antagonists & inhibitors; Atherosclerosis/complications; Atherosclerosis/drug therapy; Benzaldehydes/therapeutic use; Dyslipidemias/complications; Neovascularization, Pathologic/complications; Neovascularization, Pathologic/drug therapy; Oximes/therapeutic use; 1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism; Animals; Atherosclerosis/metabolism; Atherosclerosis/pathology; Dyslipidemias/metabolism; Dyslipidemias/pathology; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Male; Neovascularization, Pathologic/metabolism; Neovascularization, Pathologic/pathology; Rats, Sprague-Dawley; Vasa Vasorum/drug effects; Vasa Vasorum/metabolism; Vasa Vasorum/pathology; Vascular Endothelial Growth Factor A/metabolism

Key words

Atherosclerosis; HIF-1α; VEGF; darapladib; dislipidemia; vasa vasorum.

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Benzaldehydes / 1-Alkyl-2-acetylglycerophosphocholine Esterase / Atherosclerosis / Dyslipidemias / Neovascularization, Pathologic Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Cardiovasc Hematol Agents Med Chem Journal subject: ANGIOLOGIA / CARDIOLOGIA / FARMACOLOGIA / HEMATOLOGIA / QUIMICA / QUIMICA CLINICA Year: 2018 Document type: Article Affiliation country: Indonesia Country of publication: Netherlands

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