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Relationship between amorphous solid dispersion in vivo absorption and in vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport.
Wilson, Venecia; Lou, Xiaochun; Osterling, Donald J; Stolarik, Deanne F; Jenkins, Gary; Gao, Wenqing; Zhang, Geoff G Z; Taylor, Lynne S.
Affiliation
  • Wilson V; Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States.
  • Lou X; Drug Product Development, Research & Development, AbbVie, 1 N. Waukegan Road, North Chicago, IL 60064, United States.
  • Osterling DJ; Drug Metabolism and Pharmacokinetics, Research & Development, AbbVie, 1 N. Waukegan Road, North Chicago, IL 60064, United States.
  • Stolarik DF; Drug Metabolism and Pharmacokinetics, Research & Development, AbbVie, 1 N. Waukegan Road, North Chicago, IL 60064, United States.
  • Jenkins G; Drug Metabolism and Pharmacokinetics, Research & Development, AbbVie, 1 N. Waukegan Road, North Chicago, IL 60064, United States.
  • Gao W; Drug Metabolism and Pharmacokinetics, Research & Development, AbbVie, 1 N. Waukegan Road, North Chicago, IL 60064, United States.
  • Zhang GGZ; Drug Product Development, Research & Development, AbbVie, 1 N. Waukegan Road, North Chicago, IL 60064, United States. Electronic address: geoff.gz.zhang@abbvie.com.
  • Taylor LS; Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States. Electronic address: lstaylor@purdue.edu.
J Control Release ; 292: 172-182, 2018 12 28.
Article in En | MEDLINE | ID: mdl-30408553
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylthiohydantoin / Antineoplastic Agents Limits: Animals Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: United States Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylthiohydantoin / Antineoplastic Agents Limits: Animals Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: United States Country of publication: Netherlands