Sesaminol diglucoside, a water-soluble lignan from sesame seeds induces brown fat thermogenesis in mice.
Biochem Biophys Res Commun
; 507(1-4): 155-160, 2018 12 09.
Article
in En
| MEDLINE
| ID: mdl-30415772
ABSTRACT
Brown adipose tissue (BAT) is the site of non-shivering thermogenesis in mammals, wherein energy is dissipated as heat. We observed that aqueous extract of black sesame seed triggers an increase in the expression of Uncoupling Protein 1 (UCP1) in brown adipocytes from mice. The active component from the extract was purified and identified to be sesaminol diglucoside (SDG). SDG treatment decreased mass of white fat pads and serum glucose levels and increased UCP1 levels in BAT thereby protecting mice against high fat induced weight gain. Further in silico and in vitro studies revealed that these effects are due to the agonist like behaviour of SDG towards beta 3 adrenergic receptors (ß3-AR). Together, our results suggest that SDG induces BAT mediated thermogenesis through ß3-AR and protects mice against diet-induced obesity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seeds
/
Adipose Tissue, Brown
/
Lignans
/
Thermogenesis
/
Sesamum
/
Dioxoles
/
Furans
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2018
Document type:
Article
Affiliation country:
India