Erythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPKs activation through erythropoietin receptors on Schwann cells in a rat model of peripheral neuropathy.

Huang, Chun-Ta; Chen, Seu-Hwa; Lin, Shih-Chang; Chen, Wei-Ting; Lue, June-Horng; Tsai, Yi-Ju

Huang, Chun-Ta; Chen, Seu-Hwa; Lin, Shih-Chang; Chen, Wei-Ting; Lue, June-Horng; Tsai, Yi-Ju.

Affiliation

Huang CT; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chen SH; Department of Anatomy, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Lin SC; Division of Allergy and Immunology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan.
Chen WT; Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Lue JH; Graduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Tsai YJ; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Glia ; 66(11): 2299-2315, 2018 11.

Article in En | MEDLINE | ID: mdl-30417431

Subject(s)

Erythropoietin/therapeutic use; Microglia/metabolism; Mitogen-Activated Protein Kinase Kinases/metabolism; Neuralgia/drug therapy; Polyradiculoneuropathy/drug therapy; Receptors, Erythropoietin/metabolism; Schwann Cells/metabolism; Action Potentials/drug effects; Animals; Cytokines/metabolism; Disease Models, Animal; Gene Expression Regulation/drug effects; Hyperalgesia/drug therapy; Male; Median Nerve/pathology; Microglia/drug effects; Neuralgia/etiology; Pain Threshold/drug effects; Peripheral Nervous System Diseases/complications; Phosphorylation/drug effects; Polyradiculoneuropathy/etiology; RNA, Small Interfering/therapeutic use; Rats; Rats, Sprague-Dawley; Receptors, Erythropoietin/genetics; Schwann Cells/drug effects; Signal Transduction/drug effects

Key words

Schwann cell; erythropoietin; median nerve; microglia; neuropathic pain

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyradiculoneuropathy / Schwann Cells / Erythropoietin / Receptors, Erythropoietin / Microglia / Mitogen-Activated Protein Kinase Kinases / Neuralgia Type of study: Etiology_studies / Qualitative_research Limits: Animals Language: En Journal: Glia Journal subject: NEUROLOGIA Year: 2018 Document type: Article Affiliation country: Taiwan Country of publication: United States

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