Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malaria.
Am J Trop Med Hyg
; 39(1): 26-32, 1988 Jul.
Article
in En
| MEDLINE
| ID: mdl-3041855
ABSTRACT
Antibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P. vivax in humans which suppress infectivity of the parasites to the vector at high concentrations can, at lower concentrations, have the opposite effect and enhance the level of malaria infection in the mosquitoes. Infectivity enhancing effects of up to 12-fold were demonstrated when a transmission blocking monoclonal antibody and immune human sera were diluted, in some undiluted immune human sera, and in the sera of vivax malaria patients during convalescence after drug cure.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium vivax
/
Antibodies, Protozoan
/
Insect Vectors
/
Malaria
/
Anopheles
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Am J Trop Med Hyg
Year:
1988
Document type:
Article
Affiliation country:
Sri Lanka