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Ursolic acid loaded-mesoporous bioglass/chitosan porous scaffolds as drug delivery system for bone regeneration.
Ge, Yu-Wei; Lu, Jia-Wei; Sun, Zhen-Yu; Liu, Zhi-Qing; Zhou, Jun; Ke, Qin-Fei; Mao, Yuan-Qing; Guo, Ya-Ping; Zhu, Zhen-An.
Affiliation
  • Ge YW; Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
  • Lu JW; The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, China.
  • Sun ZY; Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
  • Liu ZQ; Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
  • Zhou J; The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, China.
  • Ke QF; The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, China.
  • Mao YQ; Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Electronic address: 13761360486@163.com.
  • Guo YP; The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, China. Electronic address: ypguo@shnu.edu.cn.
  • Zhu ZA; Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Electronic address: zhuzhenan2006@126.com.
Nanomedicine ; 18: 336-346, 2019 06.
Article in En | MEDLINE | ID: mdl-30419364
ABSTRACT
Bioglass scaffolds have great application potentials in orthopedics, and Ursolic acid (UA) can effectively promote in vivo new bone formation. Herein, we for the first time developed the mesoporous bioglass/chitosan porous scaffolds loaded with UA (MBG/CS/UA) for enhanced bone regeneration. The MBG microspheres with particle sizes of ~300 nm and pore sizes of ~3.9 nm were uniformly dispersed on the CS films. The mesoporous structure within the MBG microspheres and the hydrogen bonding between the scaffolds and UA drugs made the MBG/CS/UA scaffolds have controlled drug release performances. The as-released UA drugs from the scaffolds increased remarkably the alkaline phosphatase activity, osteogenic differentiation related gene type I collagen, runt-related transcription factor 2 expression, and osteoblast-associated protein expression. Moreover, the results of micro-CT images, histomorphological observations demonstrated that the MBG/CS/UA scaffolds improved new bone formation ability. Therefore, the MBG/CS/UA porous scaffolds can be used as novel bone tissue engineering materials.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Bone Regeneration / Ceramics / Drug Delivery Systems / Chitosan / Tissue Scaffolds Limits: Animals / Female / Humans Language: En Journal: Nanomedicine Journal subject: BIOTECNOLOGIA Year: 2019 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Bone Regeneration / Ceramics / Drug Delivery Systems / Chitosan / Tissue Scaffolds Limits: Animals / Female / Humans Language: En Journal: Nanomedicine Journal subject: BIOTECNOLOGIA Year: 2019 Document type: Article Affiliation country: China