Prolonged central apnoea after intravenous morphine administration in a 12-year-old male with a UGT1A1 loss-of-function polymorphism.

Toce, Michael S; Kim, Hyun; Chung, Sarita; Krauss, Baruch S

Toce, Michael S; Kim, Hyun; Chung, Sarita; Krauss, Baruch S.

Affiliation

Toce MS; Division of Emergency Medicine, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Kim H; Harvard Medical Toxicology Program, Boston Children's Hospital, Boston, MA, USA.
Chung S; Clinical Pharmacogenomics Service, Boston Children's Hospital, Boston, MA, USA.
Krauss BS; Division of Emergency Medicine, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Br J Clin Pharmacol ; 85(1): 258-262, 2019 01.

Article in En | MEDLINE | ID: mdl-30421550

Subject(s)

Analgesics, Opioid/adverse effects; Apnea/chemically induced; Morphine/adverse effects; Pain/drug therapy; Administration, Intravenous; Analgesics, Opioid/administration & dosage; Analgesics, Opioid/pharmacokinetics; Child; Fibula/injuries; Fractures, Multiple/complications; Glucuronosyltransferase/genetics; Glucuronosyltransferase/metabolism; Humans; Loss of Function Mutation; Male; Morphine/administration & dosage; Morphine/pharmacokinetics; Pain/etiology; Pharmacogenomic Testing; Polymorphism, Single Nucleotide; Tibial Fractures/complications

Key words

emergency medicine; genetic polymorphism; opioids; pain; pharmacogenomics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Apnea / Analgesics, Opioid / Morphine Type of study: Etiology_studies Limits: Child / Humans / Male Language: En Journal: Br J Clin Pharmacol Year: 2019 Document type: Article Affiliation country: United States

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